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Women may also be more likely than men to have bone fractures in the upper arm, hand, or foot while taking metformin and rosiglitazone. Reports of new onset or exacerbation of congestive heart failure occurred at a rate of 1% for insulin alone, and 2% (4 mg) and 3% (8 mg) for insulin in combination with rosiglitazone. 3%, respectively) were observed for rosiglitazone maleate alone and in combination with other hypoglycemic agents. Lower pre-treatment hemoglobin/hematocrit levels in patients enrolled in the metformin and rosiglitazone combination therapy clinical trials may have contributed to the higher reporting rate of anemia in these studies [see Adverse Reactions (6. No increase in fracture rates was observed in men treated with rosiglitazone.

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